Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells
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چکیده
منابع مشابه
the relationship between individual versus pair writing tasks and levels of fluency, complexity and accuracy in efl writing by iranian learners
پژوهش کنونی با هدف مطالعه رابطه بین نوشتار بصورت انفرادی و گروهی با میزان دقت، پیچیدگی و سلاست دانش آموزان زبان انگلیسی حین نگارش متون انجام شده است. بمنظور دستیابی به این هدف، دو گروه از دانش آموزان مقطع متوسطه موسسه زبان کیش انتخاب شده و سپس از آنها خواسته شد تا 6 متن را با 6 موضوع متفاوت و طی 6 جلسه به نگارش در آورند. تجزیه و تحلیل این پژوهش با هدف اندازه گیری میزان دقت، پیچیدگی و سلاست نوشت...
15 صفحه اولAlisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells
Colorectal cancer (CRC) is one of the most common malignancies worldwide with substantial mortality and morbidity. Alisertib (ALS) is a selective Aurora kinase A (AURKA) inhibitor with unclear effect and molecular interactome on CRC. This study aimed to evaluate the molecular interactome and anticancer effect of ALS and explore the underlying mechanisms in HT29 and Caco-2 cells. ALS markedly ar...
متن کاملAurora-A inhibition offers a novel therapy effective against intracranial glioblastoma.
Glioblastoma remains a devastating disease for which novel therapies are urgently needed. Here, we report that the Aurora-A kinase inhibitor alisertib exhibits potent efficacy against glioblastoma neurosphere tumor stem-like cells in vitro and in vivo. Many glioblastoma neurosphere cells treated with alisertib for short periods undergo apoptosis, although some regain proliferative activity upon...
متن کاملCisplatin‐resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib
De novo and acquired resistance to platinum therapy such as cisplatin (CDDP) is a clinical challenge in gastric cancer treatment. Aberrant expression and activation of aurora kinase A (AURKA) and eukaryotic translation initiation factor 4E (eIF4E) are detected in several cancer types. Herein, we investigated the role of AURKA in CDDP resistance in gastric cancer. Western blot analysis demonstra...
متن کاملGlioblastoma and glioblastoma stem cells are dependent on functional MTH1
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with poor prognosis. Cancer cells are characterized by a specific redox environment that adjusts metabolism to its specific needs and allows the tumor to grow and metastasize. As a consequence, cancer cells and especially GBM cells suffer from elevated oxidative pressure which requires antioxidant-defense and other sanitation e...
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ژورنال
عنوان ژورنال: Journal of Neuro-Oncology
سال: 2019
ISSN: 0167-594X,1573-7373
DOI: 10.1007/s11060-019-03164-5